Creating a clot adhesive stentriever to treat acute ischemic stroke (AIS)
The clinical need:
In AIS patients where mechanical thrombectomy (MT) leads to successful reperfusion only one-half have a favorable clinical outcome
Journal of NeuroInterventional Surgery | 2021 | Vol 13:14-18
Complete reperfusion on the first device pass - a major determinant of good outcomes - is achieved today in fewer than 30% of cases
Zaidat et al. | First Pass Effect - A New Measure for Stroke Thrombectomy Devices | Stroke | 2018
Most emboli released during MT are small and may cause vessel obstructions not detectable by angiography and therefore not considered in TIPI ratings
Frontiers in Neurology | May 2020 | Vol. 11 Article 386
There is an unmet need for treatment of occlusions is distal vessel which represent up to 40% of AIS incidents and are caused in part by embolization from thrombectomy procedures in more proximal vessels.
Saver at al., Thrombectomy for Distal, Medium Vessel Occlusions - A Consensus Statement on Present Knowledge and Promising Directions. Stroke. September 2020;51:2872–2884.
Our evidence:
Promising results for KAPTO coating on stentrievers in cranial flow model
Clot engagement
Better adhesion between clots and coated stentrievers than with bare metal devices
Incidence of clots detaching from stentriever before captured in catheter
Distal embolization
Coated stentrievers better captured emboli released during the retrieval, reducing the number of emboli flushed distally
Amount of particles collected at the
distal end of the cranial model
“KAPTO’s technology to target NETs is well-founded in basic science. The coating creates a differentiated stent retriever that actively binds with elements of the embolus to reduce the risk of distal embolization.”
Supporting current and emerging stroke treatment
Expanded stentriever practice
Kapto’s coating supports current stentriever applications
well-established treatment methods for large vessel occlusions (LVO); and
emerging techniques for more distal medium vessel occlusions (MeVO).
“Treatment of distal vessel occlusions is the next frontier in endovascular thrombectomy. ”
Supporting unmet needs for distal vessel occlusion (DVO)
Clot removal from remote, small and fragile vessels requires very low-profile or compressible retrieval devices.
Additional clot engagement provided by the Kapto coating is especially relevant for such devices with very small surface areas.
“About 70% of operators felt that appropriate tools to treat MeVO stroke do not exist or that current devices could be improved.”